硝化作用
化学
区域选择性
亚硝酸盐
硝基
金属
戒指(化学)
药物化学
组合化学
硝酸盐
有机化学
催化作用
烷基
作者
Yina Li,Xuelin Li,Jin-Bo Wu,Hong Jiang,Zhenhua Liu,Yu Guo,Yao‐Fu Zeng,Zhen Wang
摘要
A metal-free coupling of quinoxalin-2(1H)-ones with tert-butyl nitrite has been developed. Distinctly from the previous functionalization of quinoxalin-2(1H)-ones, this nitration reaction took place selectively at the C7 or C5 position of the phenyl ring, affording a series of 7-nitro and 5-nitro quinoxalin-2(1H)-ones in moderate to good yields. Preliminary mechanistic studies revealed that the reaction may involve a radical process.
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