Metal-Mediated and Catalyzed Difunctionalization of Unsaturated Organics

The transition-metal catalyzed difunctionalization of unsaturated organics is a powerful bond-forming strategy in organic chemistry. Installing combinations of amino-, oxo-, carbo-, and halo-groups across a carbon–carbon double or triple bond allows for rapid build-up of molecular complexity in a highly selective and efficient fashion. This chapter focuses on reactions of the general type where a transition metal mediates the addition of coupling partners across a double or triple bond. Reactions in which the transition metal plays an ancillary role (not adding across or binding to the unsaturated species) are not covered. Given the expansive scope of the topic, the material in this chapter is not intended to be comprehensive in nature; instead, the chapter is written with the goal of showcasing a general landscape of the topics covered within. Representative examples have been chosen in order to highlight the state of the art and draw attention to outstanding challenges and limitations of current methods.