医学
易损斑块
纤维帽
血管内超声
光学相干层析成像
心脏病学
急性冠脉综合征
内科学
炎症
冠状动脉
病理
放射科
动脉
心肌梗塞
作者
John J. Squiers,J. Michael DiMaio
标识
DOI:10.1016/j.jacc.2021.07.028
摘要
Plaque rupture is the most common cause of acute coronary syndromes and sudden cardiac death. Characteristics and pathobiology of vulnerable plaques prone to plaque rupture have been studied extensively over 2 decades in humans using optical coherence tomography (OCT), an intravascular imaging technique with micron scale resolution. OCT studies have identified key features of plaque vulnerability and described the in vivo characteristics and spatial distribution of thin cap fibroatheromas as major precursors to plaque rupture. In addition, OCT data supports the evolving understanding of coronary heart disease as a panvascular process associated with inflammation. In the setting of high atherosclerotic burden, plaque ruptures often occur at multiple sites in the coronary arteries, and plaque progression and healing are dynamic processes modulated by systemic risk factors. This review details major investigations with intravascular OCT into the biology and clinical implications of plaque vulnerability and plaque rupture.
科研通智能强力驱动
Strongly Powered by AbleSci AI