间充质干细胞
脐带
造血干细胞移植
移植物抗宿主病
干细胞
CXCL1型
移植
生物
归巢(生物学)
医学
免疫学
CXCR4型
髓样
癌症研究
造血
骨髓
造血干细胞
脐带血
祖细胞
炎症
趋化因子
病理
细胞生物学
内科学
生态学
作者
Rui Wang,Xiaoqi Wang,Shijie Yang,Yunshuo Xiao,Yulin Jia,Jiangfan Zhong,Qiangguo Gao,Xi Zhang
出处
期刊:Cytotherapy
[Elsevier]
日期:2021-11-01
卷期号:23 (11): 996-1006
被引量:14
标识
DOI:10.1016/j.jcyt.2021.07.009
摘要
Background aims Human mesenchymal stem cells (MSCs) from various tissues have emerged as attractive candidates for the prevention and treatment of graft-versus-host disease (GVHD). However, the molecular machinery that defines and channels the behavior of these cells remains poorly understood. Methods In this study, the authors compared the efficacy of four tissue-derived MSC types in controlling GVHD in a murine model and investigated their immunomodulatory effects. Results Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) effectively decreased the incidence and severity of GVHD, which was mediated by the enrichment of myeloid-derived suppressor cells in GVHD target tissues. RNA sequencing results showed that hUCMSCs highly expressed CXCL1. Conclusions These results suggest a novel prophylactic application of hUCMSCs for controlling GVHD after allogeneic hematopoietic stem cell transplantation.
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