化学
催化作用
试剂
基质(水族馆)
联轴节(管道)
杂原子
电化学
组合化学
甲烷氧化偶联
基础(拓扑)
有机化学
戒指(化学)
物理化学
电极
工程类
数学分析
地质学
海洋学
机械工程
数学
作者
Sushobhan Chowdhury,Shubham Pandey
标识
DOI:10.1002/ajoc.202100514
摘要
Abstract Functionalization of Csp 3 −H bond meets various challenges owing to their well‐known inertness. The task becomes even more challenging for carbon‐heteroatom coupling e. g., Csp 3 −O coupling. Herein we report an electrochemical approach for the direct regioselctive cross‐dehydrogenative hetero‐coupling of benzylic Csp 3 −H bonds of toluidines with alcohols at room temperature under external catalyst, oxidant and base‐free condition. The developed protocol utilizes benzylic substrates as the limiting reagent for the site‐selective coupling and demonstrates wide substrate scope with respect to both the coupling partners synthesizing corresponding benzylic ethers in moderate to excellent yields.
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