Research progress of sphingosine-1-phosphate and lung disease

Sphingosine-1-phosphate is one of the important components of a biologically active membrane and sphingolipid metabolites.It is important signaling molecules which regulates many biological functions in intracellular and extracellular.S1P combining with five kinds of G protein-coupled receptor subtypes(S1PR1-S1PR5) have different biological functions,including the regulation of cell proliferation,survival,apoptosis,inflammation and angiogenesis.Recent studies show that S1P and S1PR/SPHK play the important role in the development of lung disease,especially in bronchial asthma,pulmonary fibrosis,pneumonia,bronchiectasis,chronic obstructive pulmonary disease(COPD) and lung cancer.These studies may provide a new approach for the treatment of lung diseases.