生物结合
点击化学
化学
纳米技术
生物相容性材料
区域选择性
生物正交化学
组合化学
化学生物学
环加成
计算生物学
叠氮化物
有机化学
催化作用
材料科学
生物医学工程
医学
作者
Jasleen Kaur,Mokshika Saxena,Narayan Rishi
标识
DOI:10.1021/acs.bioconjchem.1c00247
摘要
Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is a modular and bio-orthogonal approach that is being adopted for the efficient synthesis of organic and bioorganic compounds. It leads to the selective formation of 1,4-disubstituted 1,2,3-triazole units connecting readily accessible building blocks via a stable and biocompatible linkage. The vast array of the bioconjugation applications of click chemistry has been attributed to its fast reaction kinetics, quantitative yields, minimal byproducts, and high chemospecificity and regioselectivity. These combined advantages make click reactions quite suitable for the lead identification and the development of pharmaceutical agents in the fields of medicinal chemistry and drug discovery. In this review, we have outlined the key aspects, the mechanistic details and merits and demerits of the click reaction. In addition, we have also discussed the recent pharmaceutical applications of click chemistry, ranging from the development of anticancer, antibacterial, and antiviral agents to that of biomedical imaging agents and clinical therapeutics.
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