Physiological Effect and Therapeutic Application of Alpha Lipoic Acid

α-硫辛酸 阿尔法(金融) 抗氧化剂 生物化学 药理学 化学 医学 外科 结构效度 患者满意度
作者
Sungmi Park,Udayakumar Karunakaran,Nam Ho Jeoung,Jae‐Han Jeon,In‐Kyu Lee
出处
期刊:Current Medicinal Chemistry [Bentham Science Publishers]
卷期号:21 (32): 3636-3645 被引量:97
标识
DOI:10.2174/0929867321666140706141806
摘要

Reactive oxygen species and reactive nitrogen species promote endothelial dysfunction in old ageand contribute to the development of cardiovascular diseases such as atherosclerosis, diabetes, and hypertension. α-lipoic acid was identified as a catalytic agent for oxidative decarboxylation of pyruvate and α-ketoglutarate in 1951, and it has been studied intensively by chemists, biologists, and clinicians who have been interested in its role in energetic metabolism and protection from reactive oxygen species-induced mitochondrial dysfunction. Consequently, many biological effects of α- lipoic acid supplementation can be attributed to the potent antioxidant properties of α-lipoic acid and dihydro α-lipoic acid. The reducing environments inside the cell help to protect from oxidative damage and the reduction-oxidation status of α-lipoic acid is dependent upon the degree to which the cellular components are found in the oxidized state. Although healthy young humans can synthesize enough α-lipoic acid to scavenge reactive oxygen species and enhance endogenous antioxidants like glutathione and vitamins C and E, the level of α-lipoic acid significantly declines with age and this may lead to endothelial dysfunction. Furthermore, many studies have reported α-lipoic acid can regulate the transcription of genes associated with anti-oxidant and anti-inflammatory pathways. In this review, we will discuss recent clinical studies that have investigated the beneficial effects of α-lipoic acid on endothelial dysfunction and propose possible mechanisms involved.
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