化学
立体中心
环糊精
对映体
色谱法
高效液相色谱法
相(物质)
手性柱色谱法
离子液体
硫酸化
离子强度
胺气处理
有机化学
组合化学
水溶液
对映选择合成
催化作用
生物化学
作者
Apryll M. Stalcup,Kyung H. Gahm
摘要
A new sulfated β-cyclodextrin (degree of substitution ≈ 13−14/cyclodextrin) bonded chiral stationary phase (CSP) for high-performance liquid chromatography is introduced. The novel CSP was used to resolve a number of enantiomeric pairs, including antihistamines, antidepressants and phenylhydantoins, using HPLC under a variety of mobile phase conditions. Among the 33 analytes successfully enantioresolved, all but six had some amine functionality. Generally, the best separations were obtained for analytes in which the stereogenic center was either incorporated in a ring system or positioned between two aromatic rings. Retention seemed to arise from either inclusion complexation or electrostatic interactions. Ionic strength and pH were found to influence chiral recognition.
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