A Platelet Activating Factor Antagonist Attenuates the Effects of Testicular Ischemia

No AccessJournal of UrologyTestis1 Sep 1997A Platelet Activating Factor Antagonist Attenuates the Effects of Testicular Ischemia Jeffrey S. Palmer, William J. Cromie, Louis F. Plzak, and Alan R. Leff Jeffrey S. PalmerJeffrey S. Palmer More articles by this author , William J. CromieWilliam J. Cromie More articles by this author , Louis F. PlzakLouis F. Plzak More articles by this author , and Alan R. LeffAlan R. Leff More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64420-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Platelet activating factor, a biochemical marker and lipid mediator of ischemic injury, has been demonstrated in several organ systems. The objective of this study was to investigate the possible role of platelet activating factor in testicular ischemic injury. Materials and Methods: Five groups of 6 male Sprague-Dawley rats were studied, including group 1-nonoperated controls, group 2-sham operated controls, group 3-those that underwent administration of 10 micro g./kg. exogenous platelet activating factor into the left testicular artery, group 4-those that underwent 4 hours of testicular ischemia and group 5-those that received pretreatment with 0.4 mg./kg. of the platelet activating factor antagonist CV-6209 intravenously before 4 hours of testicular ischemia. Ipsilateral and contralateral testes were examined histologically and seminiferous tubular diameters were measured. Results: Exogenous platelet activating factor administration in group 3 and 4 hours of ischemia in group 4 resulted in a similar extent of histological degeneration of the experimental testicle. Pretreatment with CV-6209 in group 5 resulted in a marked decrease in hemorrhagic discoloration, vascular congestion and histological changes noted with ischemia in group 4. 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Google Scholar From the Sections of Urology and Pulmonary/Critical Care Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byPalmer L (2012) Editorial CommentJournal of Urology, VOL. 188, NO. 4S, (1422-1422), Online publication date: 1-Oct-2012. Volume 158Issue 3September 1997Page: 1186-1190 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Jeffrey S. Palmer More articles by this author William J. Cromie More articles by this author Louis F. Plzak More articles by this author Alan R. Leff More articles by this author Expand All Advertisement PDF downloadLoading ...