受体
胎牛血清
细胞毒性T细胞
细胞毒性
效应器
生物
细胞培养
免疫学
分子生物学
胎儿
细胞生物学
体外
生物化学
遗传学
怀孕
作者
Sidney H. Golub,Marc G. Golightly,John V. Zielske
标识
DOI:10.1002/ijc.2910240302
摘要
Abstract Human peripheral blood lymphocytes (PBL) were found to be highly cytotoxic to a human malignant melanoma target cell line after the PBL were cultured in medium supplemented with 20% fetal bovine serum (FBS). The effector cells had surface markers similar to those of non‐cultured NK effectors against melanoma targets. Both NK (without culture) and the culture‐induced cytotoxic effectors had Fcγ receptors, lacked Fcμ receptors and were either heterogeneous for E receptors or had low‐affinity E receptors. Cells required to generate the FBS response were sensitive to anti‐T serum plus complement, passed through a nylon‐fiber column, formed E rosettes, but lacked detectable receptors for the Fc portions of either IgG or IgM. These results suggest that events causing activation of T cells such as culture of PBL in FBS‐containing medium, result in the augmentation of NK activity.
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