化学
脱氨基
序列(生物学)
钥匙(锁)
半胱氨酸
组合化学
立体化学
有机化学
生物化学
酶
计算机科学
计算机安全
作者
Alfredo González,Daniel Pérez,Carles Puig,Hamish Ryder,Jordi Sanahuja,Laia Solé,Jordi Bach
标识
DOI:10.1016/j.tetlet.2009.03.118
摘要
A practical and efficient three-step sequence for the deamination of α-aminoesters is reported. This method is based on the NaBH4-mediated selective reduction of α-diazoesters to α-hydrazonoesters and has been successfully applied to the deamination of several representative α-aminoesters including some l-cysteine ethyl ester derivatives, key intermediates in the synthesis of a series of CysLT1 antagonists.
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