Skin ageing and its treatment

老化 皮肤病科 医学 内科学
作者
Leslie Baumann
出处
期刊:The Journal of Pathology [Wiley]
卷期号:211 (2): 241-251 被引量:469
标识
DOI:10.1002/path.2098
摘要

Abstract The effects of chronic sun exposure on skin are readily apparent when skin not typically exposed to the sun and skin regularly exposed to the sun are compared. While the sun is not the only aetiological factor in the dynamic process of skin ageing, it is the primary exogenous cause among several internal and environmental elements. Thus, photo‐ageing, the main focus of this article, is a subset of extrinsic skin ageing. The influence of the sun in extrinsic skin ageing, as well as its role in potentially altering the normal course of intrinsic (also known as natural or cellular) ageing, is discussed. Telomeres, the specialized structures found at the ends of chromosomes, are believed to be integral to cellular ageing as well as in the development of cancer. The ageing process, both intrinsic and extrinsic, is also believed to be influenced by the formation of free radicals, also known as reactive oxygen species. The loss of collagen is considered the characteristic histological finding in aged skin. Wrinkling and pigmentary changes are directly associated with photo‐ageing and are considered its most salient cutaneous manifestations. Such photodamage represents the cutaneous signs of premature ageing. In addition, deleterious consequences of chronic sun exposure, specifically various forms of photo‐induced skin cancer, are also linked to acute and chronic sun exposure. The only known strategies aimed at preventing photo‐ageing include sun avoidance, using sunscreens to block or reduce skin exposure to UV radiation, using retinoids to inhibit collagenase synthesis and to promote collagen production, and using anti‐oxidants, particularly in combination, to reduce and neutralize free radicals. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚好完成签到,获得积分10
刚刚
ptyss发布了新的文献求助10
1秒前
Enkcy发布了新的文献求助10
2秒前
不配.应助徐智秀采纳,获得20
2秒前
Unicorn完成签到,获得积分10
2秒前
小龙女发布了新的文献求助10
6秒前
6秒前
Bear完成签到 ,获得积分10
8秒前
万能图书馆应助Enkcy采纳,获得10
9秒前
11秒前
富贵发布了新的文献求助10
12秒前
长情的猕猴桃完成签到,获得积分10
13秒前
13秒前
情怀应助半烟采纳,获得10
13秒前
薰硝壤应助苏苏采纳,获得10
13秒前
xianyu完成签到,获得积分10
13秒前
徐智秀完成签到,获得积分20
15秒前
19秒前
东西南北完成签到,获得积分20
19秒前
wuyang发布了新的文献求助10
20秒前
一二完成签到,获得积分10
21秒前
不配.应助黄阿鹏采纳,获得10
22秒前
23秒前
iNk应助一念之间采纳,获得10
23秒前
wang发布了新的文献求助10
25秒前
orixero应助富贵采纳,获得10
25秒前
25秒前
Orange应助科研通管家采纳,获得10
26秒前
科研通AI2S应助科研通管家采纳,获得10
26秒前
领导范儿应助科研通管家采纳,获得10
26秒前
科研通AI2S应助科研通管家采纳,获得10
26秒前
充电宝应助科研通管家采纳,获得10
26秒前
26秒前
科研通AI2S应助科研通管家采纳,获得10
26秒前
共享精神应助科研通管家采纳,获得10
26秒前
26秒前
爆米花应助科研通管家采纳,获得10
26秒前
26秒前
奶油泡fu完成签到 ,获得积分10
27秒前
28秒前
高分求助中
The Oxford Handbook of Social Cognition (Second Edition, 2024) 1050
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Chen Hansheng: China’s Last Romantic Revolutionary 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3141291
求助须知:如何正确求助?哪些是违规求助? 2792288
关于积分的说明 7802124
捐赠科研通 2448479
什么是DOI,文献DOI怎么找? 1302606
科研通“疑难数据库(出版商)”最低求助积分说明 626650
版权声明 601237