Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like

Ubiquitin-mediated degradation influences embryonic axis formation by regulating the stability of ventrally expressed transcription factors, although it is unclear whether dorsal factors are similarly modulated. In Zebrafish, the E3 ubiquitin ligase Lnx-l acts on the dorsal transcriptional repressor Boz to control dorso-ventral axis formation.