主轴装置
皮质(解剖学)
细胞皮质
细胞生物学
张力(地质)
生物
形态发生
神经科学
解剖
细胞分裂
材料科学
细胞骨架
细胞
遗传学
基因
极限抗拉强度
冶金
作者
Agathe Chaigne,Clément Campillo,Nir S. Gov,Raphaël Voituriez,Cécile Sykes,Marie‐Hélène Verlhac,Marie-Émilie Terret
摘要
Cell mechanics control the outcome of cell division. In mitosis, external forces applied on a stiff cortex direct spindle orientation and morphogenesis. During oocyte meiosis on the contrary, spindle positioning depends on cortex softening. How changes in cortical organization induce cortex softening has not yet been addressed. Furthermore, the range of tension that allows spindle migration remains unknown. Here, using artificial manipulation of mouse oocyte cortex as well as theoretical modelling, we show that cortical tension has to be tightly regulated to allow off-center spindle positioning: a too low or too high cortical tension both lead to unsuccessful spindle migration. We demonstrate that the decrease in cortical tension required for spindle positioning is fine-tuned by a branched F-actin network that triggers the delocalization of myosin-II from the cortex, which sheds new light on the interplay between actin network architecture and cortex tension.
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