Templating Synthesis of Preloaded Doxorubicin in Hollow Mesoporous Silica Nanospheres for Biomedical Applications

Advanced MaterialsVolume 22, Issue 46 p. 5255-5259 Communication Templating Synthesis of Preloaded Doxorubicin in Hollow Mesoporous Silica Nanospheres for Biomedical Applications Yang Zhao, Yang Zhao Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040Search for more papers by this authorLi-Ning Lin, Li-Ning Lin Department of Materials of Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China)Search for more papers by this authorYang Lu, Yang Lu Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040Search for more papers by this authorShao-Feng Chen, Shao-Feng Chen Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040Search for more papers by this authorLiang Dong, Liang Dong Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040Search for more papers by this authorShu-Hong Yu, Corresponding Author Shu-Hong Yu [email protected] Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040.Search for more papers by this author Yang Zhao, Yang Zhao Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040Search for more papers by this authorLi-Ning Lin, Li-Ning Lin Department of Materials of Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China)Search for more papers by this authorYang Lu, Yang Lu Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040Search for more papers by this authorShao-Feng Chen, Shao-Feng Chen Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040Search for more papers by this authorLiang Dong, Liang Dong Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040Search for more papers by this authorShu-Hong Yu, Corresponding Author Shu-Hong Yu [email protected] Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040.Search for more papers by this author First published: 22 October 2010 https://doi.org/10.1002/adma.201002395Citations: 150Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Hollow mesoporous silica (HMS) spheres preloaded with the anticancer drug Doxorubicin (DOX) can be synthesized by using porous CaCO3 spheres as templates (see figure). With good biocompatibility, the HMS@DOX spheres exhibit a greatly enhanced therapeutic effect towards tumor cells ; this enhancement may be caused by the efficient protection of DOX and the pH-sensitive release of DOX, together with enhanced intracellular delivery. Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description adma_201002395_sm_suppl.pdf1.9 MB suppl Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1 a) D. Peer, J. M. Karp, S. Hong, O. C. Farokhzad, R. Margalit, R. Langer, Nat. Nanotechnol. 2007, 2, 751; b) B. Fadeel, A. E. Garcia-Bennett, Adv. Drug Deliv. 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