以法林
促红细胞生成素肝细胞(Eph)受体
神经突
轴突引导
神经科学
生物
嗅球
受体
受体酪氨酸激酶
轴突
细胞生物学
中枢神经系统
信号转导
遗传学
体外
作者
Pan Gao,Congcong Sun,Xin‐Fu Zhou,Emanuel DiCicco‐Bloom,Renping Zhou
标识
DOI:10.1002/(sici)1097-4547(20000515)60:4<427::aid-jnr1>3.0.co;2-d
摘要
The Eph family of tyrosine kinase receptors and ligands play key roles in cell segregation and axon targeting in the developing nervous system. Interactions between the ligands and receptors cause repulsion or degeneration of receptor-positive axons from several brain regions including the retina, hippocampus, thalamus, and midbrain dopaminergic system. We extend these previous observations by showing that three A-ephrins also negatively regulate the growth of neurites from striatal and olfactory neurons. In addition to negative effects, however, we also report a trophic activity of the A-ephrins: Ephrin-A2 and A5 promote survival and neurite outgrowth of sympathetic neurons. These observations provide support to the notion that ephrins may function as either negative or positive signals in the developing nervous system. J. Neurosci. Res. 60:427–436, 2000 © 2000 Wiley-Liss, Inc.
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