生物碱
立体化学
生药学
化学
植物
生物
传统医学
生物活性
生物化学
体外
医学
作者
Ichiro Takano,Ichiro Yasuda,Motohiro NISHIJIMA,Yukio Hitotsuyanagi,Koichi Takeya,Hideji Itokawa
摘要
Three oxygenated cephalotaxine ester-type alkaloids, 11α-hydroxyhomodeoxyharringtonine (1), 11β-hydroxyhomodeoxyharringtonine (2) and 11β-hydroxydeoxyharringtonine (3) were isolated from Cephalotaxus harringtonia var. drupacea. Their structures were established by spectroscopic methods including 2D NMR and CD spectra, and their antileukemic activity was evaluated using P-388 leukemia cells.
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