New Oxygenated Cephalotaxus Alkaloids from Cephalotaxus harringtonia var. drupacea

Three oxygenated cephalotaxine ester-type alkaloids, 11α-hydroxyhomodeoxyharringtonine (1), 11β-hydroxyhomodeoxyharringtonine (2) and 11β-hydroxydeoxyharringtonine (3) were isolated from Cephalotaxus harringtonia var. drupacea. Their structures were established by spectroscopic methods including 2D NMR and CD spectra, and their antileukemic activity was evaluated using P-388 leukemia cells.