立体中心
奥西多尔
环加成
伊萨丁
1,3-偶极环加成
光学活性
化学
冷凝
偶极子
缩合反应
组合化学
有机化学
立体化学
对映选择合成
催化作用
物理
热力学
作者
Mingxia Ma,Yuan‐Yuan Zhu,Quantao Sun,Xiaoyuan Li,Jinhuan Su,Long Zhao,Yanyan Zhao,Shuai Qiu,Wenjin Yan,Kairong Wang,Rui Wang
摘要
A new strategy for the construction of optically active 5'-CF3 spiro[pyrrolidin-3,2'-oxindole] was described. A series of unprecedented 1,3-dipoles were obtained by condensation of CF3CH2NH2 with isatins. The 1,3-dipolar cycloaddition reactions of these ketimines with enals gave the products bearing four contiguous stereogenic centers in excellent yields, diastereoselectivities and enantioselectivities.
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