The effect of elemental content on the risk of dental fluorosis and the exposure of the environment and population to fluoride produced by coal-burning

Endemic fluorosis is a geochemical disease that affects thousands of people. Growing evidence from domestic and foreign studies indicate that fluorosis is associated with an abnormal level of the elements (such as F, Ca, Fe, Mg, Cu, Zn, P) in the environment and a population exposed to fluoride. To study the effect of the elemental content on the risk of dental fluorosis, the content of 25 elements in the environment produced by coal-burning and a population exposed to fluoride was determined. The results show that an abnormal level of various elements (including F, Al, Se, Zn, Cu, Fe, Mo, Mn, B, V, Ca, Mg, and P) in the population exposed to fluoride, which is related to the increasing or decreasing of the corresponding elements in the environment. Subsequent univariate and multivariate regression analyses show that high levels of F, Al, As, Pb and Cr were a risk factor for dental fluorosis, but not Se, Zn, Cu, B, Ca and P which were a protective factor for dental fluorosis. This study can provide a scientific basis for a further understanding of the causes of health damage caused by fluoride and the improvement of targeted prevention strategies.