Cell Membrane Coating Nanotechnology

Advanced MaterialsVolume 30, Issue 23 1706759 Review Cell Membrane Coating Nanotechnology Ronnie H. Fang, Ronnie H. Fang Department of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093 USASearch for more papers by this authorAshley V. Kroll, Ashley V. Kroll Department of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093 USASearch for more papers by this authorWeiwei Gao, Weiwei Gao Department of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093 USASearch for more papers by this authorLiangfang Zhang, Corresponding Author Liangfang Zhang zhang@ucsd.edu orcid.org/0000-0003-0637-0654 Department of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093 USAE-mail: zhang@ucsd.eduSearch for more papers by this author Ronnie H. Fang, Ronnie H. Fang Department of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093 USASearch for more papers by this authorAshley V. Kroll, Ashley V. Kroll Department of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093 USASearch for more papers by this authorWeiwei Gao, Weiwei Gao Department of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093 USASearch for more papers by this authorLiangfang Zhang, Corresponding Author Liangfang Zhang zhang@ucsd.edu orcid.org/0000-0003-0637-0654 Department of NanoEngineering and Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093 USAE-mail: zhang@ucsd.eduSearch for more papers by this author First published: 27 March 2018 https://doi.org/10.1002/adma.201706759Citations: 526Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Nanoparticle-based therapeutic, prevention, and detection modalities have the potential to greatly impact how diseases are diagnosed and managed in the clinic. With the wide range of nanomaterials available, the rational design of nanocarriers on an application-specific basis has become increasingly commonplace. Here, a comprehensive overview is provided on an emerging platform: cell-membrane-coating nanotechnology. As a fundamental unit of biology, cells carry out a wide range of functions, including the remarkable ability to interface and interact with their surrounding environment. Instead of attempting to replicate such functions via synthetic techniques, researchers are now directly leveraging naturally derived cell membranes as a means of bestowing nanoparticles with enhanced biointerfacing capabilities. This top-down technique is facile, highly generalizable, and has the potential to greatly augment existing nanocarriers. Further, the introduction of a natural membrane substrate onto nanoparticles surfaces has enabled additional applications beyond those traditionally associated with nanomedicine. Despite its relative youth, there exists an impressive body of literature on cell membrane coating, which is covered here in detail. Overall, there is still significant room for development, as researchers continue to refine existing workflows while finding new and exciting applications that can take advantage of this developing technology. Citing Literature Volume30, Issue23June 6, 20181706759 RelatedInformation