High SBP trajectories are associated with risk of all-cause death in general Chinese population

Objective: This study aimed to investigate whether long-term trajectories of high SBP can further predict risk of all-cause death in Chinese adults. Methods: We used a community-based cohort of 84 363 participants without myocardial infarction, stroke, or cancer, in 2010. SBP trajectories used latent mixture modeling with data from 2006, 2008, and 2010. Cox proportional hazards models were used to examine the association between SBP trajectories and risk of all-cause death in 2010–2015. Results: We identified five distinct SBP trajectory patterns based on the 2006 status and the pattern of change during 2006–2010. Each pattern was labeled according to the SBP levels and pattern over time: low-stable (n = 21 249), moderate-stable (n = 39 390), moderate-increasing (n = 9634), elevated-decreasing (n = 9094) and elevated-stable (n = 4996). During 5.24 ± 1.04 years of follow-up, we documented 4131 deaths. After adjusting for potential confounding factors and using the low-stable group as a reference, hazard ratios [95% confidence interval (CI)] of all-cause death for the moderate-stable, moderate-increasing, elevated-decreasing, and elevated-stable groups were 1.32 (1.12–1.56), 1.60 (1.26–2.04), 1.69 (1.38–2.07), and 1.75 (1.33–2.32), respectively. Although the moderate-stable trajectory exhibited SBP ranges within the ‘normal’ range (126.90–130.09 mmHg) in 2006–2010, this group had higher all-cause death risk relative to the low-stable trajectory group (109.86–112.46 mmHg) (adjusted hazard ratio = 1.32, 95% CI 1.12–1.56). Conclusion: High SBP trajectories are independent risk factors for all-cause death. Our findings suggest increasing SBP trajectories within the currently designated ‘normal’ range may still increase risk of all-cause death.