内科学
同型半胱氨酸
医学
C反应蛋白
优势比
冲程(发动机)
置信区间
萧条(经济学)
胃肠病学
物理疗法
炎症
机械工程
工程类
宏观经济学
经济
作者
Jieyun Yin,Chongke Zhong,Zhengbao Zhu,Xiaoqing Bu,Tan Xu,Libing Guo,Xuemei Wang,Jintao Zhang,Yong Cui,Dong Li,Jianhui Zhang,Zhong Ju,Chung-Shiuan Chen,Jing Chen,Yonghong Zhang,Jiang He
标识
DOI:10.1016/j.cca.2018.01.011
摘要
Homocysteine (HCY) and high sensitivity C reactive protein (hs-CRP) were suggested to be involved in post-stroke depression (PSD), which is a frequent mood disorder after stroke. However, the combined effect of HCY and hs-CRP on PSD remains unclear.A total of 598 acute ischemic stroke patients from 7 of 26 centers participating in the China Antihypertensive Trial in Acute Ischemic Stroke with HCY or hs-CRP measurements were included in this analysis. PSD status was evaluated by 24-item Hamilton Depression Rating Scale at 3 months after stroke.Two hundred and forty-one (40.30%) participants were considered as PSD. HCY and hs-CRP levels were not significantly different between PSD and non-PSD patients. Interesting, in a maximally adjusted model, the odds ratio (95% confidence interval) of PSD was 1.90 (1.18-3.06) for coexistence of HCY ≥ 14.65 μmol/l and hs-CRP ≥ 1.90 mg/l compared with the other levels (HCY < 14.65 μmol/l and/or hs-CRP < 1.90 mg/l). Adding combination of HCY and hs-CRP to a model containing conventional risk factors could significantly improve risk reclassification for PSD.Coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors.
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