Therapeutic Efficacy of a Coriolus versicolor-Based Vaginal Gel in Women with Cervical Uterine High-Risk HPV Infection: A Retrospective Observational Study

医学 阴道镜检查 细胞学 内科学 宫颈癌 妇科 HPV感染 观察研究 产科 回顾性队列研究 不利影响 癌症 病理
作者
Anna Angela Criscuolo,Francesco Sesti,Emilio Piccione,P Mancino,Elena Belloni,Cetty Gullo,Marco Ciotti
出处
期刊:Advances in Therapy [Springer Nature]
卷期号:38 (2): 1202-1211 被引量:9
标识
DOI:10.1007/s12325-020-01594-6
摘要

A Coriolus versicolor-based vaginal gel is available for treating women with cervical uterine high-risk human papillomavirus (HPV) infection through re-epithelizing and re-balancing microbiota actions. A longitudinal retrospective observational study was performed to evaluate efficacy and safety of the gel. Women treated with Coriolus versicolor-based vaginal gel were compared with women not treated with the gel. Both groups were monitored for HPV infection by an HPV DNA test, Pap smear (cytology) and colposcopy at baseline and after 6 months. Overall, 183 high-risk HPV positive women were enrolled (97 treated and 86 controls). After 6 months, the HPV DNA test became negative in 67.0% versus 37.2% of treated and controls, respectively (p < 0.0001). Furthermore, 76.1% versus 40.8% registered a colposcopy improvement (p = 0.0005) and 60.4% versus 40.8% showed a remission (p = 0.05), for treated versus controls, respectively. Regarding to cytology, 78.5% of treated versus 37.7% of controls registered an improvement, while 70.8% of treated versus 34.8% of controls had a remission (p < 0.0001 for both variables). At multivariate analyses adjusted for age, smoking habit, and use of estroprogestinic pill, compared to controls, women treated with the gel showed a significantly higher likelihood to experience the clearence of HPV DNA (OR 4.81; 95% 2.43–9.53), and remission at colposcopy (OR 2.30; 95% 1.00–5.31), and cytology (OR 5.13; 95% 2.40–10.96) at 6 months. No adverse event was reported during the follow-up. The use of a Coriolus versicolor-based vaginal gel in high-risk HPV patients is safe and effective based on all examined tests.
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