医学
阴道镜检查
细胞学
内科学
宫颈癌
妇科
HPV感染
观察研究
产科
回顾性队列研究
不利影响
癌症
病理
作者
Anna Angela Criscuolo,Francesco Sesti,Emilio Piccione,P Mancino,Elena Belloni,Cetty Gullo,Marco Ciotti
标识
DOI:10.1007/s12325-020-01594-6
摘要
A Coriolus versicolor-based vaginal gel is available for treating women with cervical uterine high-risk human papillomavirus (HPV) infection through re-epithelizing and re-balancing microbiota actions. A longitudinal retrospective observational study was performed to evaluate efficacy and safety of the gel. Women treated with Coriolus versicolor-based vaginal gel were compared with women not treated with the gel. Both groups were monitored for HPV infection by an HPV DNA test, Pap smear (cytology) and colposcopy at baseline and after 6 months. Overall, 183 high-risk HPV positive women were enrolled (97 treated and 86 controls). After 6 months, the HPV DNA test became negative in 67.0% versus 37.2% of treated and controls, respectively (p < 0.0001). Furthermore, 76.1% versus 40.8% registered a colposcopy improvement (p = 0.0005) and 60.4% versus 40.8% showed a remission (p = 0.05), for treated versus controls, respectively. Regarding to cytology, 78.5% of treated versus 37.7% of controls registered an improvement, while 70.8% of treated versus 34.8% of controls had a remission (p < 0.0001 for both variables). At multivariate analyses adjusted for age, smoking habit, and use of estroprogestinic pill, compared to controls, women treated with the gel showed a significantly higher likelihood to experience the clearence of HPV DNA (OR 4.81; 95% 2.43–9.53), and remission at colposcopy (OR 2.30; 95% 1.00–5.31), and cytology (OR 5.13; 95% 2.40–10.96) at 6 months. No adverse event was reported during the follow-up. The use of a Coriolus versicolor-based vaginal gel in high-risk HPV patients is safe and effective based on all examined tests.
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