埃尔特罗姆博帕格
造血
祖细胞
多能干细胞
干细胞
川地34
癌症研究
再生障碍性贫血
生物
免疫学
髓样
骨髓
医学
细胞生物学
血小板
免疫性血小板减少症
作者
Bruno Quintino de Oliveira,Luiz Fernando Bazzo Catto,Bárbara A. Santana,Maria Florencia Tellechea,Priscila Santos Scheucher,Phillip Scheinberg,Rodrigo T. Calado
摘要
Summary Eltrombopag has been added to first‐line treatment of immune aplastic anaemia (AA), resulting in higher responses. We analysed marrow samples of AA patients who responded to immunosuppressive therapy (IST) alone or in combination with eltrombopag for the composition of the haematopoietic stem and progenitor cell (HSPC) compartment. The number of CD34 + cells and multipotent progenitors was higher in patients treated with eltrombopag ( P < 0·005; P < 0·05; respectively), but not the number of stem cells. No aberrant phenotype was observed. These results indicate that eltrombopag augments CD34 + cells in vivo and preferentially expands multipotent progenitors, but not stem cells.
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