生物
驯化
渗入
基因组
苹果属植物
倍性
单倍型
遗传学
基因
多倍体
等位基因
进化生物学
植物
作者
Xuepeng Sun,Chen Jiao,Heidi Schwaninger,Chih-Cheng T. Chao,Yumin Ma,Naibin Duan,Awais Khan,Seunghyun Ban,Kenong Xu,Lailiang Cheng,Gan‐Yuan Zhong,Zhangjun Fei
出处
期刊:Nature Genetics
[Springer Nature]
日期:2020-11-02
卷期号:52 (12): 1423-1432
被引量:159
标识
DOI:10.1038/s41588-020-00723-9
摘要
Domestication of the apple was mainly driven by interspecific hybridization. In the present study, we report the haplotype-resolved genomes of the cultivated apple (Malus domestica cv. Gala) and its two major wild progenitors, M. sieversii and M. sylvestris. Substantial variations are identified between the two haplotypes of each genome. Inference of genome ancestry identifies ~23% of the Gala genome as of hybrid origin. Deep sequencing of 91 accessions identifies selective sweeps in cultivated apples that originated from either of the two progenitors and are associated with important domestication traits. Construction and analyses of apple pan-genomes uncover thousands of new genes, with hundreds of them being selected from one of the progenitors and largely fixed in cultivated apples, revealing that introgression of new genes/alleles is a hallmark of apple domestication through hybridization. Finally, transcriptome profiles of Gala fruits at 13 developmental stages unravel ~19% of genes displaying allele-specific expression, including many associated with fruit quality.
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