Safety and efficacy of platelet‐rich plasma vs carboxytherapy in the treatment of atrophic scars: A comparative clinical and histopathological study

Dermatologic TherapyVolume 33, Issue 6 e13942 ORIGINAL ARTICLE Safety and efficacy of platelet-rich plasma vs carboxytherapy in the treatment of atrophic scars: A comparative clinical and histopathological study Samia O. Nassar, Faculty of Medicine, Department of Dermatology and Venereology, Tanta University, Tanta, EgyptSearch for more papers by this authorRania A. R. Eltatawy, Faculty of Medicine, Department of Dermatology and Venereology, Tanta University, Tanta, EgyptSearch for more papers by this authorGhada F. R. Hassan, Corresponding Author ghadafawzy53@yahoo.com orcid.org/0000-0001-9131-0263 Faculty of Medicine, Department of Dermatology and Venereology, Tanta University, Tanta, Egypt Correspondence Ghada Fawzy Rezk Hassan, 1 Asmaa Bent Abi-Bakr Street, Neseem Street, End of Moheb Street, Al-Mahalla Al-Kobra, El-Gharbia, Egypt. Email: ghadafawzy53@yahoo.comSearch for more papers by this author Samia O. Nassar, Faculty of Medicine, Department of Dermatology and Venereology, Tanta University, Tanta, EgyptSearch for more papers by this authorRania A. R. Eltatawy, Faculty of Medicine, Department of Dermatology and Venereology, Tanta University, Tanta, EgyptSearch for more papers by this authorGhada F. R. Hassan, Corresponding Author ghadafawzy53@yahoo.com orcid.org/0000-0001-9131-0263 Faculty of Medicine, Department of Dermatology and Venereology, Tanta University, Tanta, Egypt Correspondence Ghada Fawzy Rezk Hassan, 1 Asmaa Bent Abi-Bakr Street, Neseem Street, End of Moheb Street, Al-Mahalla Al-Kobra, El-Gharbia, Egypt. Email: ghadafawzy53@yahoo.comSearch for more papers by this author First published: 30 June 2020 https://doi.org/10.1111/dth.13942Citations: 1 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Abstract Atrophic scars that occur after surgical procedure or trauma are considered as a cosmetic problem for patients. Atrophic scarring results usually during wound healing with inadequate production of collagen and connective tissue. Factors that precipitate to the formation of depressed scars include: individual variations in wound healing, wound tension, tissue apposition, and scar contraction. To evaluate the safety and efficacy of PRP vs carboxytherapy in treatment of atrophic scars. This study included 40 patients with atrophic scars divided into two groups; group A including 20 patients received PRP injection, group B including 20 patients received CO2 injection. They received the treatment every 4 weeks for four sessions and had follow up for 6 months after the end of treatment. Skin biopsies were taken before and after treatment to evaluate clinical results. There was statistically significant difference between both groups in treating atrophic scars, regarding clinical improvement and patients' satisfaction with better results in group B. Histopathological examination showed significant expression of MMP-1 in group B more than group A. Both methods were safe and effective with minimal side effects with better improvement in patients treated with carboxytherapy than those treated with PRP. Citing Literature Volume33, Issue6November/December 2020e13942 RelatedInformation