幻肢
感觉系统
物理医学与康复
幻觉痛
医学
感觉刺激疗法
神经假体
感觉阈
神经假体
物理疗法
心理学
截肢
神经科学
外科
生物医学工程
认知科学
作者
Francesco M. Petrini,Marko Bumbaširević,Giacomo Valle,Vladimir Ilić,Pavle Mijović,Paul Čvančara,Federica Barberi,Natalija Katic,Dario Bortolotti,David Andreu,Knut Lechler,Aleksandar Lešić,Sanja Mazić,Bogdan Mijović,David Guiraud,Thomas Stieglitz,Ásgeir Alexandersson,Silvestro Micera,Staniša Raspopović
出处
期刊:Nature Medicine
[Springer Nature]
日期:2019-09-01
卷期号:25 (9): 1356-1363
被引量:191
标识
DOI:10.1038/s41591-019-0567-3
摘要
Conventional leg prostheses do not convey sensory information about motion or interaction with the ground to above-knee amputees, thereby reducing confidence and walking speed in the users that is associated with high mental and physical fatigue1-4. The lack of physiological feedback from the remaining extremity to the brain also contributes to the generation of phantom limb pain from the missing leg5,6. To determine whether neural sensory feedback restoration addresses these issues, we conducted a study with two transfemoral amputees, implanted with four intraneural stimulation electrodes7 in the remaining tibial nerve (ClinicalTrials.gov identifier NCT03350061). Participants were evaluated while using a neuroprosthetic device consisting of a prosthetic leg equipped with foot and knee sensors. These sensors drive neural stimulation, which elicits sensations of knee motion and the sole of the foot touching the ground. We found that walking speed and self-reported confidence increased while mental and physical fatigue decreased for both participants during neural sensory feedback compared to the no stimulation trials. Furthermore, participants exhibited reduced phantom limb pain with neural sensory feedback. The results from these proof-of-concept cases provide the rationale for larger population studies investigating the clinical utility of neuroprostheses that restore sensory feedback.
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