胺气处理
化学
电化学
组合化学
小学(天文学)
羧酸盐
产量(工程)
盐(化学)
氧化还原
表面改性
催化作用
分子
有机化学
电极
物理
天文
物理化学
冶金
材料科学
作者
Min Huang,Jie Dai,Xu Cheng,Mengning Ding
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-09-17
卷期号:21 (19): 7759-7762
被引量:41
标识
DOI:10.1021/acs.orglett.9b02707
摘要
Direct α-phosphonylation of an unprotected secondary amine in a single step is of practical importance to amino phophophates. However, this protocol is limited due to the high redox barrier of unprotected amine. In this paper, we report C–H phosphonylation of an unprotected secondary amine via an electrochemical approach in the presence of catalytic carboxylate salt. This metal-free and exogenous oxidant-free method furnishes diverse target molecules with satisfactory yield under mild reaction conditions. Successful application of the protocol in a gram-scale experiment demonstrates the potential utility for further functionalization.
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