生物相容性
壳聚糖
纳米复合材料
肿胀 的
材料科学
粘附
多孔性
脚手架
扫描电子显微镜
背景(考古学)
活力测定
伤口愈合
化学工程
复合材料
生物医学工程
化学
细胞
外科
医学
古生物学
生物化学
工程类
冶金
生物
作者
Virgínia de Alencar Muniz Gonzaga,Alessandra Lima Poli,Juliana S. Gabriel,Daiane Y. Tezuka,Talita Alvarenga Valdes,Andrei Leitão,Camila Fernanda Rodero,Taís Maria Bauab,Marlus Chorilli,Carla C. Schmitt
摘要
Abstract The pivotal issue of skin regeneration research is the development of effective biomaterials that exhibit biological activities as fungicide and bactericide, combining simple and low cost manufacturing technologies. In this context, nanocomposite scaffolds based on chitosan (Ch)/Laponite (Lap) were produced by using different concentrations of Lap via freeze‐drying process for potential application in skin regeneration. The influence of Lap concentration on the scaffold properties was evaluated. The prepared scaffolds were characterized by x‐ray diffraction (XRD), scanning electron microscopy (SEM), porosity, swelling capacity, and mechanical analyses. The results revealed that the scaffolds exhibited a porous architecture, besides the increase in the clay content, leads to an increase in the porosity, an improvement of mechanical strength, and a decrease of swelling capacity. In vitro tests were also carried out to evaluate the biocompatibility of the materials, such as bioadhesion, antibacterial activity, viability, and cell adhesion. Viability and cell adhesion demonstrated that all scaffolds were not cytotoxic and the fibroblast cells readily attached on the surface of the scaffolds. Thereby, the results suggested that the nanocomposite scaffolds are biomaterials potentially useful as wound dressings.
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