The development of a fed-batch Corynebacterium glutamicum fermentation model

Fed-batch bioreactors are multiple input, multiple output non-linear systems with a central role in the production of antimicrobials, fine-chemicals and desirable products of pharmaceutical industry, and as such industrial microbial bio-catalytic processes require understanding of the microorganism, the bioreactor, and the set of differential equations that allow the description of the fermentation system. In the present study, we show our preliminary modelling results of growth of Corynebacterium glutamicum wild type strain ATCC13032 in a single sugar system. The differential equations consider an unstructured model of C glutamicum to describe the liquid and gas phase, and the results suggest that is possible to model the titers in the liquid and concentrations in the gas phase for the simple sugar system. We anticipate that these results are the basis for further C glutamicum fed-batch reactor modelling with other carbon sources, complex mixtures of them, implementation of novel control and optimization structures, and the development of state estimators from in-situ measurements.