Ki-67
异型性
多形性(细胞学)
核异型性
病理
医学
病态的
免疫组织化学
垂体腺瘤
临床意义
核仁
腺瘤
生物
增生
增殖细胞核抗原
细胞质
生物化学
作者
Lingchuan Guo,Yu-Shuang Zheng,Weishuo Liu,Suya Kang
标识
DOI:10.3760/cma.j.issn.1001-2346.2013.05.010
摘要
Objective To study the pathological morphologic characteristics of invasive pituitary tumors and the affect of expression of Ki-67 and MMP-9 to the tumor invasion.Methods Analyzing 130 cases of pituitary tumor specimens from January 2003 to december 2011,which divided into two groups according to invasion,observe pathological morphologic characteristics through the light and electron microscope and the expression of Ki-67 and MMP-9 via immunohistochemistry (IHC).Results The difference was statistically significant(P < 0.05) between the invasive group and noninvasive group in the incidence rate of pathological morphologic characteristics,such as high nuclearcytoplasmic ratio,cell pleomorphism,nuclear atypia,and nucleoli appearence; nuclear atypia and nucleolus margination in the invasive group were found through the electron microscopy.therein addition,significant statistical differences in the rate of Ki-67 and MMP-9 expressions were found ; the rate was higher in the invasive group than the noninvasive group(P < 0.01).Conclusions the pathological morphologic characteristics of pituitary tumor and the high expression of Ki-67 and MMP-9 were significantly valuable in the diagnosis of tumor aggressiveness,which provided valuable indicators for early clinical diagnosis of tumor invasion.
Key words:
Pituitary adenoma; Invasion; Pathological morphology; Ki-67 ; MMP-9
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