菌丝体
化学
发酵
浸渍(污水)
食品科学
灵芝
二氯甲烷
传统医学
灵芝
生物
植物
生物化学
医学
溶剂
材料科学
复合材料
作者
Tania Maria Costa,Juliana Lenzi,Hercílio Higino da Silva Filho,Juliane Araújo Greinert-Goulart,Michele Debiasi Alberton,Lorena Benathar Ballod Tavares,Débora de Olíveira
标识
DOI:10.1080/14786419.2020.1793146
摘要
Natural antiparasitic agents are used as a strategy for advances in the treatment of neglected tropical diseases (NTDs), such as giardiasis. The present paper identified the compounds produced by Ganoderma lipsiense mycelium grown in submerged fermentation and investigated the antigiardial activity potential of extracts in vitro. G. lipsiense mycelium crude extract (CE) was obtained by the maceration process and after purification in column, thirty compounds were identified by gas chromatography - mass spectrometry (GC-MS) in hexane sub-fraction (HSF). To determine the antigiardial potential, different parts of the purified CE have been evaluated, where hexane (HEXf) and dichloromethane (DCMf) fractions showed in vitro reduction levels higher than 90% of the Giardia duodenalis trophozoites at 100 μg mL-1. This antigiardial activity was investigated aiming to explore the possibility of G. lipsiense mycelium extract as a novel antigiardial compound to the treatment of human giardiasis.
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