生物利用度
介孔材料
止痛药
对乙酰氨基酚
解热药
控制释放
材料科学
药理学
化学
纳米技术
色谱法
医学
有机化学
催化作用
作者
Joanna Gościańska,Anna Olejnik,Aleksander Ejsmont,Aleksandra Galarda,Stefan Wuttke
标识
DOI:10.1016/j.jcis.2020.10.137
摘要
Paracetamol is the most commonly used antipyretic and analgesic drug in the world. The key challenge in paracetamol therapy is associated with the frequency of the dosing. Depending on the gastric filling within 10–20 min paracetamol is released and rapidly absorbed from the gastrointestinal tract. Therefore, it must be taken three or four times a day. To address the dose challenge it is desirable that the paracetamol release profile follows the zero-order kinetic model (constant rate of drug release per unit time). This goal can be achieved by using a suitable porous carrier system. Herein, non-toxic wrinkled mesoporous carbons with unique morphology were synthesized via the hard template method as new carriers for paracetamol. These particles can precisely modulate the release of paracetamol over 24 h in a simulated gastric fluid according to the zero-order kinetic model completely eliminating the initial burst release. Overall, these systems could significantly enhance the bioavailability of paracetamol and prolong its therapeutic effect in numerous diseases such as cold, flu, COVID-19, and severe pain.
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