Treatment of hepatitis B virus infection in chronic infection with HBeAg-positive adult patients (immunotolerant patients): a systematic review

医学 肝细胞癌 血清转化 内科学 随机对照试验 乙型肝炎病毒 HBeAg 乙型肝炎 观察研究 乙型肝炎表面抗原 病毒 免疫学 病毒载量 肝硬化
作者
Cristiane Valle Tovo,Marcelo Ahlert,Carine Panke,Ângelo Zambam de Mattos,Ângelo Alves de Mattos
出处
期刊:European Journal of Gastroenterology & Hepatology [Lippincott Williams & Wilkins]
卷期号:33 (5): 605-609 被引量:1
标识
DOI:10.1097/meg.0000000000001907
摘要

Recently, a controversial approach suggesting the early treatment of chronic infection with hepatitis B “e” antigen-positive patients with hepatitis B virus (HBV) infection, has been proposed. The objective of this study is to systematically review medical literature regarding treatment of HBV infection in adult chronic infection with HBeAg-positive patients. A systematic review was performed according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. Original studies that evaluated the effect of antivirals in adult chronic infection with HBeAg-positive patients were included. The outcomes of interest were viral load suppression, the loss/seroconversion of HBeAg, the loss/seroconversion of hepatitis B surface antigen, and the development of cirrhosis or hepatocellular carcinoma. The search for eligible studies was performed in Excerpta Medica dataBASE, PubMed and Cochrane databases until January 2020, without language or date restriction. The risk of bias was evaluated using the Newcastle–Ottawa Scale for observational studies and the Revised Cochrane Risk-of-Bias Tool for randomized controlled trials. Two hundred ninety-six articles were retrieved. After analyzing titles and abstracts, 287 articles were excluded and nine were considered potentially eligible. From these, five were excluded after full-text analysis. Finally, four articles were included. Only two were randomized controlled trials. All studies were carried out in Asian patients. Results were variable with regard to viral load, negativation/seroconversion of HBeAg and HBsAg. One study demonstrated that treated patients developed cirrhosis or hepatocellular carcinoma less frequently than untreated individuals. Overall, the studies were of poor quality. In conclusion, the present systematic review demonstrated that, at present, there is not enough evidence to recommend treating this population of patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
求知的周完成签到,获得积分10
刚刚
1秒前
柒柒球完成签到,获得积分10
1秒前
赵田完成签到 ,获得积分10
2秒前
2秒前
长安完成签到,获得积分10
6秒前
大橙子发布了新的文献求助10
7秒前
在水一方应助Herisland采纳,获得10
9秒前
笨笨小刺猬完成签到,获得积分10
11秒前
11秒前
科研小达人完成签到,获得积分10
14秒前
追寻凌青完成签到,获得积分10
16秒前
渡劫完成签到,获得积分10
17秒前
丫丫完成签到 ,获得积分10
17秒前
lxy发布了新的文献求助10
18秒前
bono完成签到 ,获得积分10
21秒前
DentistRui完成签到,获得积分10
21秒前
23秒前
laber应助忧伤的步美采纳,获得50
26秒前
淡淡月饼发布了新的文献求助20
27秒前
茶茶应助虞无声采纳,获得50
27秒前
大橙子发布了新的文献求助10
29秒前
wangnn完成签到,获得积分10
30秒前
xzz完成签到,获得积分10
32秒前
阿绿发布了新的文献求助10
36秒前
37秒前
量子星尘发布了新的文献求助10
37秒前
manman完成签到 ,获得积分20
40秒前
太清完成签到,获得积分10
44秒前
山雀完成签到,获得积分10
46秒前
伊一完成签到,获得积分10
48秒前
哭泣笑柳发布了新的文献求助10
54秒前
琳琅发布了新的文献求助10
59秒前
xue完成签到 ,获得积分10
1分钟前
liars完成签到 ,获得积分10
1分钟前
搞怪人雄完成签到,获得积分10
1分钟前
落后的夜阑完成签到,获得积分10
1分钟前
大橙子发布了新的文献求助10
1分钟前
彪行天下完成签到,获得积分10
1分钟前
danli完成签到 ,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022