脊髓炎
医学
脑炎
移植
造血干细胞移植
病理
免疫学
内科学
病毒
脊髓
精神科
作者
Ping Qiang,Kaidi Song,Baoling Tang,Lan Shi,Xiaoyu Zhu,Wen Yao,Lei Zhang,Wuling Zhu,Liangquan Geng,Xingbing Wang,Xin Liu,Huilan Liu,Zimin Sun,Xiaoling Ma
标识
DOI:10.1016/j.jinf.2020.08.038
摘要
Most studies emphasized cerebrospinal fluid (CSF) analysis was the main contributor to the human herpes virus-6 (HHV-6) B encephalitis/myelitis diagnosis. [1] Ward K.N. Hill J.A. Hubacek P. de la Camara R. Crocchiolo R. Einsele H. et al. Guidelines from the 2017 European Conference on Infections in Leukaemia for management of HHV-6 infection in patients with hematological malignancies and after hematopoietic stem cell transplantation. Haematologica. 2019; 104: 2155-2163 Crossref PubMed Scopus (32) Google Scholar Thus, little is known identifying HHV-6 encephalitis/myelitis without CSF samples. Here, we present the management of 17 highly suspected cases of HHV-6B encephalitis/myelitis post-cord blood transplantation (CBT) by next-generation sequencing (NGS) in peripheral blood (PB) samples. We report the characteristics and a favorable outcome by an early intervention. Transplant physicians should recognize neurological symptoms in early post transplantation as possible signs of HHV-6B encephalitis/myelitis, and should be prompted to decide on immediate intervention for early posttransplant neurological symptoms in combination with the detection of HHV-6B DNA in the PB by NGS.
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