Sensitive Determination of Folic Acid using a Solid Bismuth Microelectrode by Adsorptive Stripping Voltammetry

Abstract An adsorptive stripping voltammetric procedure of folic acid determination with the use of a new voltammetric sensor with a prolonged application‐solid bismuth microelectrode was described. The proposed microelectrode is characterized by more eco‐friendly properties as compared to in situ formed bismuth film electrodes due to the fact that bismuth ions are not needed as a component of supporting electrolyte for metal film plating. Furthermore the above mentioned fact simplifies and shortens a measurements procedure. Parameters affected folic acid determination were studied. After a procedure optimization the calibration graph was found to be linear in the range: 5×10 −10 to 1×10 −8 mol L −1 (accumulation time: 120 s). The obtained detection limit of folic acid determination for accumulation time of 120 s was 1.8×10 −10 mol L −1 . Possible interferences deriving from a presence of other organic and surface active compounds were studied. The analysis of pharmaceutical preparation was positively performed following the presented procedure.