小泡
运动性
生物物理学
人工细胞
化学
原细胞
基质(水族馆)
膜
纳米技术
细胞生物学
生物化学
材料科学
生物
生态学
作者
Subhadip Ghosh,Farzad Mohajerani,Seoyoung Son,Darrell Velegol,Peter J. Butler,Ayusman Sen
出处
期刊:Nano Letters
[American Chemical Society]
日期:2019-08-20
卷期号:19 (9): 6019-6026
被引量:53
标识
DOI:10.1021/acs.nanolett.9b01830
摘要
Autonomous nanovehicles powered by energy derived from chemical catalysis have potential applications as active delivery agents. For in vivo applications, it is necessary that the engine and its fuel, as well as the chassis itself, be biocompatible. Enzyme molecules have been shown to display enhanced motility through substrate turnover and are attractive candidates as engines; phospholipid vesicles are biocompatible and can serve as cargo containers. Herein, we describe the autonomous movement of vesicles with membrane-bound enzymes in the presence of the substrate. We find that the motility of the vesicles increases with increasing enzymatic turnover rate. The enhanced diffusion of these enzyme-powered systems was further substantiated in real time by tracking the motion of the vesicles using optical microscopy. The membrane-bound protocells that move by transducing chemical energy into mechanical motion serve as models for motile living cells and are key to the elucidation of the fundamental mechanisms governing active membrane dynamics and cellular movement.
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