孤雌内酯
三阴性乳腺癌
倍半萜内酯
表观遗传学
癌症研究
三重阴性
医学
乳腺癌
倍半萜
药理学
生物
肿瘤科
内科学
细胞凋亡
癌症
遗传学
基因
植物
作者
Thaise Gonçalves Araújo,Lara Vecchi,Paula Marynella Alves Pereira Lima,Everton Allan Ferreira,Igor Moreira Campos,Douglas Cardoso Brandão,Gabriela Silva Guimarães,Matheus Alves Ribeiro,Ademar Alves da Silva Filho
标识
DOI:10.2174/0929867326666190816230121
摘要
Triple Negative Breast Cancers (TNBC) are heterogeneous and aggressive pathologies, with distinct morphological and clinical characteristics associated with their genetic diversity, epigenetics, transcriptional changes and aberrant molecular patterns. Treatment with anti-neoplastic drugs exerts systemic effects with low specificity, and incipient improvement in overall survival due to chemoresistance and recurrence. New alternatives for TNBC treatment are urgent and parthenolide or its analogues have been explored. Parthenolide is a sesquiterpene lactone with promising antitumor effects against TNBC cell lines. This review highlights the importance of parthenolide and its analogue drugs in TNBC treatment.
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