In recent years, countries have been competing with each other to attract tourists due to of the unprecedented growth in new tourism destinations. Consequently, these countries have been taking several initiatives to improve the competitiveness of their destinations in comparison to those of other countries. However, it is becoming increasingly difficult for destinations to become the most popular and preferred choice among tourists. Previous literature has highlighted the need for examining the association between the culture of a particular destination and their competitiveness with respect to tourism. Little is known, however, about these associations at the present time. This study offers a cultural explanation of the travel and tourism competitiveness (TTC) of a country by investigating the relationship between destination competitiveness, as measured by TTC, and national culture. The study investigates these relationships by analysing data from 73 countries. Multiple regression was used to examine the relationships, and cluster analysis to segment the countries. The findings indicate that individualism, long-term orientation, and indulgence dimensions of national culture were significant in influencing the TTC of a country, whereas power distance and masculinity were insignificant. This study emphasises the importance of developing culturally congruent policies to improve destination competitiveness. • Destination competitiveness is assessed by travel and tourism competitiveness. • Travel and tourism competitiveness is influenced by the national culture of a country. • Analyses travel and tourism competitiveness data from 73 countries. • Individualism, long-term orientation, and indulgence influence travel and tourism competitiveness. • Culturally congruent policies help in improving travel and tourism competitiveness.