Transcatheter Mitral Valve Repair in Cardiogenic Shock and Mitral Regurgitation

心源性休克 四分位间距 医学 危险系数 二尖瓣反流 心脏病学 内科学 心力衰竭 休克(循环) 置信区间 死亡率 外科 心肌梗塞
作者
Richard G. Jung,Trevor Simard,Christopher P. Kovach,Kelsey M. Flint,Creighton W. Don,Pietro Di Santo,Marianna Adamo,Luca Branca,Francesca Valentini,Tomas Benito‐González,Felipe Fernández‐Vazquez,Rodrigo Estévez‐Loureiro,Alessandra Berardini,Nicolina Conti,Claudio Rapezzi,Elena Biagini,Simon Parlow,Risa Shorr,Amos Levi,Ana Manovel,Rosa Cardenal-Piris,Jose Fernandez,Mony Shuvy,Dan Haberman,Alessandra Sala,Mohamad Alkhouli,Claudia Marini,Marta Bargagna,Davide Schiavi,Paolo Denti,Sinisa Markovic,Nicola Buzzatti,Vincent Chan,Mark Hynes,Thierry Mesana,Marino Labinaz,Federico Pappalardo,Maurizio Taramasso,Benjamin Hibbert
出处
期刊:Jacc-cardiovascular Interventions [Elsevier]
卷期号:14 (1): 1-11 被引量:65
标识
DOI:10.1016/j.jcin.2020.08.037
摘要

The aim of this study was to evaluate the outcome of transcatheter mitral valve repair (TMVr) in patients with cardiogenic shock and significant mitral regurgitation (MR). Patients in cardiogenic shock with severe MR have a poor prognosis in the setting of conventional medical therapy. Because of its favorable safety profile, TMVr is being increasingly used as an acute therapy in this population, though its efficacy remains unknown. A multicenter, collaborative, patient-level analysis was conducted. Patients with cardiogenic shock and moderate to severe (3+) or severe (4+) MR who were not surgical candidates were treated with TMVr. The primary outcome was in-hospital mortality. Secondary outcomes included 90-day mortality, heart failure (HF) hospitalization, and the combined event rate of 90-day mortality and HF hospitalization following dichotomization by TMVr device success. Between January 2011 and February 2019, 141 patients across 14 institutions met the inclusion criteria. In-hospital mortality occurred in 22 patients (15.6%), at 90 days in 38 patients (29.5%), and at one year in 55 patients (42.6%). Median length of hospital stay following TMVr was 10 days (interquartile range: 6 to 20 days). HF hospitalization occurred in 26 patients (18.4%) at a median of 73 days (interquartile range: 26 to 546 days). When stratified by TMVr procedural results, successful TMVr reduced rates of in-hospital mortality (hazard ratio [HR]: 0.36; 95% confidence interval [CI]: 0.13 to 0.98; p = 0.04), 90-day mortality (HR: 0.36; 95% CI: 0.16 to 0.78; p = 0.01), and the composite of 90-day mortality and HF hospitalization (HR: 0.41; 95% CI: 0.19 to 0.90; p = 0.03). TMVr may improve short- and intermediate-term mortality in high-risk patients with cardiogenic shock and moderate to severe MR. Randomized studies are needed to definitively establish MR as a therapeutic target in patients with cardiogenic shock.
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