亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Effective connectivity among the hippocampus, amygdala, and temporal neocortex in epilepsy patients: A cortico-cortical evoked potential study

新皮层 扁桃形结构 海马体 颞叶 神经科学 癫痫 心理学 医学 功能连接
作者
Zhihao Guo,Baotian Zhao,Wenhan Hu,Chao Zhang,Xiu Wang,Yao Wang,Chang Liu,Jiajie Mo,Lin Sang,Yanshan Ma,Xiaoqiu Shao,Jianguo Zhang,Kai Zhang
出处
期刊:Epilepsy & Behavior [Elsevier BV]
卷期号:115: 107661-107661 被引量:8
标识
DOI:10.1016/j.yebeh.2020.107661
摘要

Objective Mesial temporal lobe epilepsy (MTLE) is one of the most common types of intractable epilepsy. The hippocampus and amygdala are two crucial structures of the mesial temporal lobe and play important roles in the epileptogenic network of MTLE. This study aimed to explore the effective connectivity among the hippocampus, amygdala, and temporal neocortex and to determine whether differences in effective connectivity exist between MTLE patients and non-MTLE patients. Methods This study recruited 20 patients from a large cohort of drug-resistant epilepsy patients, of whom 14 were MTLE patients. Single-pulse electrical stimulation (SPES) was performed to acquire cortico-cortical evoked potentials (CCEPs). The root mean square (RMS) was used as the metric of the magnitude of CCEP to represent the effective connectivity. We then conducted paired and independent sample t-tests to assess the directionality of the effective connectivity. Results In both MTLE patients and non-MTLE patients, the directional connectivity from the amygdala to the hippocampus was stronger than that from the hippocampus to the amygdala (P < 0.01); the outward connectivity from the amygdala to the cortex was stronger than the inward connectivity from the cortex to the amygdala (P < 0.01); the amygdala had stronger connectivity to the neocortex than the hippocampus (P < 0.01). In MTLE patients, the neocortex had stronger connectivity to the hippocampus than to the amygdala (P < 0.01). No significant differences in directional connectivity were noted between the two groups. Conclusions A unique effective connectivity pattern among the hippocampus, amygdala, and temporal neocortex was identified through CCEPs analysis. This study may aid in our understanding of physiological and pathological networks in the brain and inspire neurostimulation protocols for neurological and psychiatric disorders.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
小师叔完成签到,获得积分10
3秒前
5秒前
xiaoyu发布了新的文献求助10
9秒前
11秒前
13秒前
孙孙应助lQ采纳,获得10
13秒前
田一点发布了新的文献求助10
16秒前
田一点完成签到,获得积分10
21秒前
wansida完成签到,获得积分10
25秒前
喜悦宫苴完成签到,获得积分10
25秒前
30秒前
32秒前
辉哥发布了新的文献求助10
36秒前
量子星尘发布了新的文献求助10
37秒前
Lyl完成签到 ,获得积分10
40秒前
煜清清完成签到 ,获得积分10
46秒前
和谐山灵完成签到,获得积分20
49秒前
CodeCraft应助TIANNANXING采纳,获得10
51秒前
Akim应助辉哥采纳,获得10
51秒前
嗨是完成签到,获得积分10
53秒前
53秒前
56秒前
英俊的铭应助耷拉地啦采纳,获得10
59秒前
yang完成签到,获得积分10
59秒前
搜集达人应助一只小锦鲤采纳,获得10
1分钟前
情怀应助白日梦采纳,获得10
1分钟前
NeilGu完成签到,获得积分10
1分钟前
1分钟前
星期五完成签到,获得积分10
1分钟前
TIANNANXING发布了新的文献求助10
1分钟前
聪明小于完成签到 ,获得积分10
1分钟前
1分钟前
火星上誉完成签到 ,获得积分10
1分钟前
1分钟前
天天摸鱼完成签到,获得积分10
1分钟前
zhao完成签到,获得积分10
1分钟前
FashionBoy应助木讷山采纳,获得10
1分钟前
1分钟前
1分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976600
求助须知:如何正确求助?哪些是违规求助? 3520689
关于积分的说明 11204470
捐赠科研通 3257316
什么是DOI,文献DOI怎么找? 1798683
邀请新用户注册赠送积分活动 877881
科研通“疑难数据库(出版商)”最低求助积分说明 806613