拉曼散射
生物分子
分子
光学
拉曼光谱
散射
材料科学
纳米技术
化学
物理
有机化学
作者
Tae‐Woong Koo,Sin-Lam Chan,Andrew A. Berlin
出处
期刊:Optics Letters
[The Optical Society]
日期:2005-05-01
卷期号:30 (9): 1024-1024
被引量:79
摘要
We report on the applicability of combining surface-enhanced Raman scattering (SERS) with coherent anti-Stokes Raman scattering for high-sensitivity detection of biological molecules. We found that this combination of techniques provides more than 3 orders of signal enhancement compared with SERS and permits monitoring of biological molecules such as deoxyguanosine monophosphate (dGMP) and deoxyadenosine monophosphate at the single-molecule level. This combined technique also improved detection sensitivity for angiotensin peptide. As this is believed to be the first report of detection of dGMP at the single-molecule level, we suggest that this approach can serve as a new tool for biological studies.
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