破折号
认知功能衰退
认知
地中海饮食法
痴呆
治疗饮食
睡眠剥夺对认知功能的影响
脑老化
老年学
神经保护
干预(咨询)
医学
心理学
临床心理学
人口学
内科学
精神科
疾病
社会学
计算机科学
操作系统
作者
Martha Clare Morris,Christy Tangney,Yamin Wang,Frank M. Sacks,Lisa L. Barnes,David A. Bennett,Neelum T. Aggarwal
标识
DOI:10.1016/j.jalz.2015.04.011
摘要
Introduction The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific to the nutrition literature on dementia prevention. Methods We devised the Mediterranean‐Dietary Approach to Systolic Hypertension (DASH) diet intervention for neurodegenerative delay (MIND) diet score that specifically captures dietary components shown to be neuroprotective and related it to change in cognition over an average 4.7 years among 960 participants of the Memory and Aging Project. Results In adjusted mixed models, the MIND score was positively associated with slower decline in global cognitive score (β = 0.0092; P < .0001) and with each of five cognitive domains. The difference in decline rates for being in the top tertile of MIND diet scores versus the lowest was equivalent to being 7.5 years younger in age. Discussion The study findings suggest that the MIND diet substantially slows cognitive decline with age. Replication of these findings in a dietary intervention trial would be required to verify its relevance to brain health.
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