摘要
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Aug 2001CHRONIC SACRAL NEUROMODULATION IN PATIENTS WITH LOWER URINARY TRACT SYMPTOMS: RESULTS FROM A NATIONAL REGISTER M. SPINELLI, P. BERTAPELLE, F. CAPPELLANO, A. ZANOLLO, R. CARONE, F. CATANZARO, G. GIARDIELLO, F. DE SETA, and ON BEHALF OF THE GINS GROUP* M. SPINELLIM. SPINELLI , P. BERTAPELLEP. BERTAPELLE , F. CAPPELLANOF. CAPPELLANO , A. ZANOLLOA. ZANOLLO , R. CARONER. CARONE , F. CATANZAROF. CATANZARO , G. GIARDIELLOG. GIARDIELLO , F. DE SETAF. DE SETA , and ON BEHALF OF THE GINS GROUP* View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65979-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The Italian Register was created in February 1997 to collect the national results of sacral neuromodulation. All Italian centers at which sacral neuromodulation is performed were invited to participate in our study. We present the results from retrospective and prospective registers. Materials and Methods: A total of 196 patients underwent permanent implantation of sacral neuromodulation and were enrolled in the Italian register. There were 18 males and 75 females in the retrospective, and 28 males and 75 females in the prospective studies. Student’s t test was used to compare paired values, and the Wilcoxon rank sum and nonparametric tests were used when necessary. Results: Mean incontinent episodes daily plus or minus standard deviation for patients with detrusor instability went from 5.4 ± 3.9 to 1.1 ± 1.6 (median 5 and 0, respectively) at 12-month followup (p <0.001). For idiopathic retention average residual volume decreased from 277 to 108 cc (median 287 and 80, respectively), and 50% of patients stopped catheterization and another 13% catheterized once daily at 1-year after implantation. With neurogenic voiding disturbances, the results fluctuated with time from a minimum of 33% to a maximum 66% of patients who did not catheterize at 6-month followup and 12 months after implantation, respectively. At 12-month followup, 50% of patients with hyperreflexia had less than 1 incontinent episode daily. The problem was completely solved in 66% of patients in the retention group. Of patients in the urge incontinent population 39% were completely dry and 23% had less than 1 incontinent episode daily. Conclusions: Sacral neuromodulation is effective therapy for treating lower urinary tract symptoms resistant to less invasive therapy. References 1 : The standardisation of terminology of lower urinary tract function. The International Continence Society Committee on Standardisation of Terminology. Scand J Urol Nephrol1988; 114: 5. Google Scholar 2 Urinary Incontinence in Adults: Clinical Practice Guideline. Urinary Incontinence Guideline Panel AHPCR Pub No. 96–0682. Rockville: Agency for Health Care Policy and Research, Public Health Service, United States Department of Health and Human Services1996. Google Scholar 3 : Detrusor inhibition induced by stimulation of pudendal nerve afferents. Neurourol Urodyn1986; 5: 381. Google Scholar 4 : Detrusor inhibition on selective pudendal nerve stimulation in the perineum. Neurourol Urodyn1988; 6: 389. Google Scholar 5 : Suppression of normal human voiding reflexes by electrical stimulation of the dorsal penile nerve. Eur Urol1998; 33: 60. Google Scholar 6 : Effects of sacral segmental nerve stimulation on urethral resistance and bladder contractility: how does neuromodulation work in urge incontinence patients?. Neurourol Urodyn1995; 14: 502. Google Scholar 7 : Bladder contractility and idiopathic detrusor instability in the female. Br J Urol1993; 72: 559. Google Scholar 8 : Different voiding dynamics in stable and unstable bladders with and without outlet obstruction. Neurourol Urodyn1998; 17: 473. Google Scholar 9 : Predictors of success with neuromodulation in lower urinary tract dysfunction: results of trial stimulation in 100 patients. J Urol1994; 152: 2071. Link, Google Scholar 10 : Sacral (S3) segmental nerve stimulation as a treatment for urge-incontinence in patients with detrusor instability: results of chronic electrical stimulation using an implantable neural prosthesis. J Urol1995; 154: 504. Link, Google Scholar 11 : Management of voiding dysfunction with an implantable neuroprosthesis. Urol Clin North Am1992; 19: 163. Google Scholar 12 : Functional evaluation of sacral nerve root integrity. Report of a technique. Urology1990; 35: 388. Google Scholar 13 : Quality of life of persons with urinary incontinence: development of a new measure. Urology1996; 47: 67. Google Scholar 14 : Sacral nerve stimulation for treatment of refractory urinary urge incontinence. J Urol1999; 162: 352. Link, Google Scholar 15 : Early onset and persistency of neuromodulation for detrusor hyper-reflexia in patients with a spinal cord injury. Neurourol Urodyn1998; 17: 411. Google Scholar 16 : Treatment of refractory urge urinary incontinence with sacral spinal nerve stimulation in multiple sclerosis patients. Lancet1996; 348: 717. Google Scholar 17 : Functional rehabilitation of the neurogenic bladder by chronic sacral neuromodulation. Akt Urol1996; 27: 89. Google Scholar 18 : Abnormal electromyographic activity of the urethral sphyncter, voiding dysfunction and polycystic ovaries: a new syndrome?. Br Med J1988; 297: 1436. Google Scholar 19 : A PET study on brain control of micturition in humans. Brain1997; 120: 111. Google Scholar 20 : Intravesical resiniferatoxin for the treatment of hypersensitive disorder: a randomized placebo controlled study. J Urol2000; 164: 676. Link, Google Scholar From the Osp. Fornaroli, Magenta, CTO/CRF/MA, Torino, Policlinico Multimedica, Sesto S. Giovanni and Medtronic, Milano, Italy© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBertapelle P, Bodo G and Carone R (2018) Detrusor Acontractility in Urinary Retention: Detrusor Contractility Test as Exclusion Criteria for Sacral NeurostimulationJournal of Urology, VOL. 180, NO. 1, (215-216), Online publication date: 1-Jul-2008.GUYS J, HADDAD M, PLANCHE D, TORRE M, LOUIS-BORRIONE C and BREAUD J (2018) SACRAL NEUROMODULATION FOR NEUROGENIC BLADDER DYSFUNCTION IN CHILDRENJournal of Urology, VOL. 172, NO. 4 Part 2, (1673-1676), Online publication date: 1-Oct-2004. Volume 166Issue 2August 2001Page: 541-545 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsurinary tractquality of lifeurinary incontinencereflex, abnormalurinary retentionMetricsAuthor Information M. SPINELLI More articles by this author P. BERTAPELLE More articles by this author F. CAPPELLANO More articles by this author A. ZANOLLO More articles by this author R. CARONE More articles by this author F. CATANZARO More articles by this author G. GIARDIELLO More articles by this author F. DE SETA More articles by this author ON BEHALF OF THE GINS GROUP* Participants: R. Bonini and L. Spreafico, Osp. E. Franchini, Montecchio E.; G. Tuccitto and G. Anselmo, Osp. Cà Foncello, Treviso; E. Ostardo and A. Garbeglio, Osp. S. M. degli Angeli, Pordenone; A. Cisternino and F. Pagano, Osp. Clin. Universitario, Padova; E. Gianneo and G. Comeri, Osp. S. Anna, Como; M. Schettini, Osp. S. Giovanni di Dio e Ruggi D’Aragona, Salerno; A. Centemero and C. Guazzoni, Osp. Ville Turro, Milano; G. Del Popolo and G. Lombardi, Osp. Careggi, Firenze; C. Simeone and S. Cosciani, Spedali Civili, Brescia; M. Cervigni and F. Natale, Osp. S. Carlo di Nancy, Roma; R. Vallone and E. Cruciani, Osp. Generale S. G. Calibita Fatebenefratelli, Roma; D. Pistolesi and C. Selli, Spedali Riuniti di S. Chiara, Pisa; M. Pastorello and A. Molon, Osp. Sacro Cuore, Negrar; A. D’Amico and P. Curti, Pol. Borgoroma Verona; C. A. Levorato and A. Lembo, Osp. Riuniti, Bergamo; E. Kocjancic and B. Frea, Osp. Maggiore, Novara; A. De Marco and P. Quattrone, CTO, Napoli; D. Minardi and G. Muzzonigro, Pol. Umberto I, Ancona; G. Giocoli Nacci and A. Pagliarulo, Policlinico di Bari; E. Andretta and G. Signorelli, Dolo; and G. La Pira and G. Degrande, Siracusa. More articles by this author Expand All Advertisement PDF downloadLoading ...