Trophoblast Cell Surface Antigen 2 (Trop2) in Chromophobe Renal Cell Carcinoma

Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities. The prognostic value of Trop2 in renal cell renal carcinoma (RCC), especially in non-clear cell RCC, is still unclear.To evaluate the prognostic impact of Trop2 expression in a large cohort of patients with chromophobe (ch)RCC.Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimen were analyzed for Trop2 expression by immunohistochemistry.81 chRCC patients were eligible for analysis, of these 24 (29.6%) patients were positive for Trop2. No significant associations were found for Trop2 expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in 5-year overall survival for Trop2- compared to Trop2+ (89.6% versus 100.0%; p=0.288).In chRCC Trop2 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC further studies with larger cohorts are warranted.