纳米地形
细胞生物学
细胞外基质
生物物理学
细胞粘附
材料科学
粘附
化学
细胞
纳米技术
细胞外
机械生物学
纤维连接蛋白
电池类型
机械转化
作者
Jian Luo,Matthew Walker,Yufang Xiao,Hannah Donnelly,Matthew J. Dalby,Manuel Salmerón-Sánchez
标识
DOI:10.1016/j.bioactmat.2021.11.024
摘要
Nanotopography presents an effective physical approach for biomaterial cell manipulation mediated through material-extracellular matrix interactions. The extracellular matrix that exists in the cellular microenvironment is crucial for guiding cell behaviours, such as determination of integrin ligation and interaction with growth factors. These interactions with the extracellular matrix regulate downstream mechanotransductive pathways, such as rearrangements in the cytoskeleton and activation of signal cascades. Protein adsorption onto nanotopography strongly influences the conformation and distribution density of extracellular matrix and, therefore, subsequent cell responses. In this review, we first discuss the interactive mechanisms of protein physical adsorption on nanotopography. Secondly, we summarise advances in creating nanotopographical features to instruct desired cell behaviours. Lastly, we focus on the cellular mechanotransductive pathways initiated by nanotopography. This review provides an overview of the current state-of-the-art designs of nanotopography aiming to provide better biomedical materials for the future.
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