[Research progress of epigenetic regulation in the pathogenesis of aluminum exposure].

Aluminum is one of the most abundant elements on earth. Aluminum compounds are widely used in food additives, antacids, cooking utensils and so on. Human exposure to aluminum is mainly through diet and drinking water, while excessive intake of aluminum can accumulate in tissues and cause toxic reactions. In the central nervous system, aluminum exposure is closely related to a series of nervous system diseases such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Epigenetic modification refers to the regulation of gene expression without changing the DNA sequence, and its regulatory disorders can lead to abnormalities and diseases of the central nervous system. This paper describes the regulation of epigenetics and its components, including DNA methylation, histone modification and non-coding RNA, in aluminum-induced neurotoxicity, in order to provide insights into the epigenetic mechanism of aluminum-induced neurotoxicity.铝是地球上储量最丰富的元素之一，铝化合物广泛应用于食品添加剂、抗酸剂和炊具等。人类接触铝主要通过饮食和饮水摄入，而过量铝摄入会在组织中蓄积并引起毒性反应。在中枢神经系统中，铝暴露与阿尔茨海默病、帕金森病和肌萎缩侧索硬化症等一系列神经系统疾病的发生密切相关。表观遗传学修饰是指在不改变DNA序列的情况下调节基因表达，其调控失调会导致中枢神经系统异常和疾病。本文通过阐述表观遗传学及其组成部分，包括DNA甲基化、组蛋白修饰和非编码RNA在铝致神经毒性中的调控作用，为铝暴露致神经毒性在表观遗传方面的机制研究提供分析。.