氧化应激
DNA损伤
双酚A
有机体
兴奋
抗氧化剂
雌激素受体
生物
污染物
化学
DNA
细胞内
生物化学
细胞生物学
遗传学
生态学
乳腺癌
有机化学
环氧树脂
癌症
作者
Ivana Ďurovcová,Stanislav Kyzek,Jana Fabová,Jana Makuková,Eliška Gálová,Andrea Ševčovičová
标识
DOI:10.1016/j.envpol.2022.119346
摘要
Bisphenol A (BPA), as a major component of some plastic products, is abundant environmental pollutant. Due to its ability to bind to several types of estrogen receptors, it can trigger multiple cellular responses, which can contribute to various manifestations at the organism level. The most studied effect of BPA is endocrine disruption, but recently its prooxidative potential has been confirmed. BPA ability to induce oxidative stress through increased ROS production, altered activity of antioxidant enzymes, or accumulation of oxidation products of biomacromolecules is observed in a wide range of organisms - estrogen receptor-positive and -negative. Subsequently, increased intracellular oxidation can lead to DNA damage induction, represented by oxidative damage, single- and double-strand DNA breaks. Importantly, BPA shows several mechanisms of action and can trigger adverse effects on all organisms inhabiting a wide variety of ecosystem types. Therefore, the main aim of this review is to summarize the genotoxic effects of BPA on organisms across all taxa.
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