医学
钙蛋白酶
内科学
地中海饮食法
克罗恩病
疾病
人口
科克伦图书馆
粪钙保护素
队列
前瞻性队列研究
胃肠病学
队列研究
炎症性肠病
随机对照试验
环境卫生
作者
Mawada Jaber,Mohammad Altamimi,Almothana Altamimi,Sara Cavalière,Francesca De Filippis
标识
DOI:10.1177/02601060221102281
摘要
Background The pathogenesis and clinical course of Crohn's disease (CD) is influenced by diet. Mediterranean Diet (MD) helps Crohn's patients through many mechanisms. Aims This study aimed to evaluate the effect of the MD on CD patients and to evaluate such effect on body parameters. Methods PubMed, Science Direct, Web of Science, MEDLINE and Cochrane central library were searched for MD and CD from 2010 to 2020. Included studies met the following criteria: (1) male and female adults (18–75 years) with a confirmed diagnosis of CD; (2) MD as an intervention; (3) original interventional Trial, Cross-Sectional Analysis, or Prospective Cohort Studies. Results Five studies were included, involving 83,564 participants. A small number of patients with CD fulfilled the P-MDS criteria, the overall scores were low, 4.7 and 4.5 for females and males respectively. Patients with an inactive disease whose adherence to MD was greater, the MD score was negatively correlated with disease activity (p <0.001) and positively with IBDQ (p = 0.008). Twenty-seven percent had a prevalence of impaired adherence to a MD (mMED score = 0–2), giving such a population a risk attributed to 12% for the later CD. Seventy-point reduction in CDAI + decreased fecal CRP / calprotectin, calprotectin <250 mcg/gm or >50% decrease from baseline and hsCRP < 5 mg/L or >50% from baseline. Conclusions MD showed anti-inflammatory properties. Adherence to MD was associated with improvement in CD patients and negatively correlated with the disease activity, in addition to a lower risk of developing CD later in life.
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